![]() Kidney functional mass slowly declines after age 35. Jain is also a co-senior author on another of the studies, published in Nature Communications, that maps healthy and injured cellular neighborhoods in areas where kidney stones form, and identifies biomarkers in the urine that are unique to patients with kidney stone disease. The new research is one of nine studies, published simultaneously across the Nature Portfolio journals, introducing the first set of maps created by researchers at institutions supported by HuBMAP. The study also received support from HuBMAP, an NIH Common Fund-sponsored program that aims to spatially define every cell in the healthy human body, and the Human Cell Atlas, an international research effort to gather information on at least 10 billion human cells. It is working to do so with the help of participants with kidney disease who are willing to undergo kidney biopsies solely to contribute to research. The Kidney Precision Medicine Project, also supported by the NIH, aims to improve kidney disease treatment. Kim, MD, an associate professor of surgery, worked with other members of the Kidney Precision Medicine Project (KPMP), Human BioMolecular Atlas Program (HuBMAP), Human Cell Atlas, and scientists from other institutions to complete single-cell and spatial tests on nearly 100 healthy and diseased human kidneys. Gaut, MD, PhD, the Ladenson Professor of Pathology & Immunology Anitha Vijayan, MD, a professor of medicine in the Division of Nephrology and Eric H. ![]() Jain’s team, including co-investigators Joseph P. ![]() This molecular knowledge will, one day, lead us to precise, customized treatments for our patients.” “By mapping molecular signatures, we hope to predict which patients are at risk of progressing to kidney failure. “We don’t have great treatment options for patients with kidney disease,” said Sanjay Jain, MD, PhD, a Washington University professor of medicine who led this study with five co-corresponding authors. The study, funded by the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health (NIH), is published July 19 in Nature. Altogether, they created a comprehensive 2D and 3D map of kidney cell organization and molecular identity in healthy and diseased kidneys. They uncovered diverse cellular microcosms with rich genetic signatures along segments of the kidney associated with kidney failure in patients or recovery from injury. The aim of the kidney tissue atlas is to further the understanding of kidney injury and disease.īuilding on previous work showing 30 cell types in the kidney, the researchers revealed 51 cell types, some rare and novel, in the healthy kidney and 28 related cell types with features associated with injury or recovery. Louis are among the leaders of a multi-institution research team that has built an atlas focused on the kidney’s myriad cells. Scientists at Washington University School of Medicine in St. Louis helped lead a major study, funded by the National Institutes of Health (NIH), that uncovered rich cellular and molecular diversity in healthy and diseased kidneys, creating a kidney tissue atlas that will help further understanding of kidney injury and disease. ![]() Researchers at Washington University School of Medicine in St. Research collaboration details molecular knowledge, step toward personalized medicine Our flat organizational structure allows for real relationships and quick resolutions without the tangled web of unneeded bureaucracy.News Release Kidney tissue atlas serves as blueprint for understanding kidney injury, disease Our boutique company is highly specialized in geriatric care and offers unmatched customer service. Benchmark Therapies proudly serves the senior population in nursing homes, skilled nursing facilities, adult day programs, personal care homes and assisted living communities. We believe the only way to thrive is to innovate and we are constantly evolving to meet the changing needs of our patients, our clients, and our team members. Our dedication to this vision has yielded undeniable care outcomes and fostered a strong company culture of motivated therapists who feel valued and have the resources required to be true clinicians - all while improving the financial outcomes for our clients. Benchmark Therapies is a contract therapy company that was formed in 2005 by a single therapist with a vision of creating a therapy provider that truly focused on innovative, patient-centered care by kind, passionate therapists - all while maintaining a partnership approach with clients. ![]()
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